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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) of more than 27, given that they also suffer from weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% rather than participants who have been given placebos) during a 12- month period, while a separate study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err to the side of caution and allow the FDA do its job and demand some study be done so the public understands the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on their medications.

Researchers found that participants using this drug for a year, lost excess weight within a month and have kept the load off during the entire 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which can be made up of several active ingredient, which can make them far better and safer.

Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular could be the fact that at the time of right now there aren't any long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure levels and heartrate, and must not be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.


Approving a drug using this many potentially lethal side effects is inconsistent while using mission statement from the FDA. The power of the drug manufacturing lobby is blatantly evident within the approval of countless drugs requiring 'post-marketing' studies which might be clearly significant to overall drug safety inside US.