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The Food and Drug Administration, FDA, has approved the drug Vivitrol for that treatment of opioid dependence according to a news release by them on 10-12-2010.

Using two separate drugs to shed weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err to the side of caution and allow the FDA do its job and demand some investigation be done so the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on his or her medications.

Researchers discovered that participants investing in this drug for any year, lost weight within a month and have kept the weight off during the entire 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that since right now there are no long term prescription slimming capsules that have been licensed by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise hypertension and heartrate, and must not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.


Approving a drug with this many potentially lethal unwanted side effects is inconsistent with all the mission statement with the FDA. The power of the drug manufacturing lobby is blatantly evident within the approval of numerous drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety inside US.